The presence of hyperglycemia, dysregulated recruitment of neutrophils and macrophages, increased expression of proinflammatory cytokines including interleukin (IL)-1β, IL-6, tumor necrosis factor (TNF)-α, and IL-8, matrix metalloproteinases (MMPs), and serine proteases in the wound contribute to chronic inflammation and non-healing [4,7]. The gene discussed is TNF; the disease is Hyperglycemia.