POLB and cancer: It should also be investigated what the implication of this incorrect ribonucleotide incorporation of ITP across dT is in cancer cells, where cells grow faster than normal cells and the need for nucleotide is greater for the completion of DNA replication, and many non-replicative DNA polymerase, including polη and polβ, engage in the DNA incorporation and bypass of DNA lesions including inosine to ensure the completion of DNA replication, which can cause many incorrect incorporations.