EIF2AK3 and gastric cancer: The PERK-CHOP axis-mediated ER stress and apoptosis induced by celastrol, a bioactive compound from Tripterygium wilfordii, induces ER stress-mediated apoptosis through the PERK-CHOP signaling cascade in gastric cancer cells; this effect in SGC-7901 and BGC-823 gastric cancer cells are inhibited when combined with the ROS scavenger NAC treatment [50].