To investigate the role of BGN-expressing CAFs in the tumor microenvironment, CAFs in the scRNAseq dataset were classified into CAF_BGN_High and CAF_BGN_Low groups based on BGN expression levels in a cluster of CAFs (scaled expression > 3 or ≤3, respectively) in the public database of ESCC tissues. This evidence concerns the gene BGN and esophageal squamous cell carcinoma.