SERPINE1 and obesity due to melanocortin 4 receptor deficiency: Inflammation in obesity can increase the activity of lactate dehydrogenase, C-reactive protein (CRP), and plasminogen activator inhibitor-1 (PAI-1), thereby enhancing lactate oxidation, LDL expression in neurons, and mitochondrial ROS synthesis, leading to neurodegeneration and memory impairment [140].