Multiple microRNAs, miR-142-3p, miR-34a, miR-129-5p, and miR-451, directly target HMGB1 to restore caspase activation and suppress autophagy in doxorubicin-resistant breast cancer, AML, retinoblastoma, and pediatric AML [79,140,141,142,143,144] (Figure 3). The gene discussed is HMGB1; the disease is acute myeloid leukemia.