HMGB1 and neuroblastoma: Similarly, in neuroblastoma, endogenous HMGB1 regulates chemotherapy-induced pyroptosis through the ROS/ERK1/2/caspase-3/GSDME signaling axis, where, surprisingly, its knockdown inhibited chemotherapy-induced pyroptosis and switched the cell death mode to apoptosis, and thereby increased sensitivity to chemotherapeutic agents [187].