HMGB1 and pancreatic neoplasm: Furthermore, in pancreatic cancer, ferroptosis-driven release of oncogenic KRASG12D protein, a process facilitated by HMGB1-associated autophagic secretion, educates tumor-associated macrophages towards a pro-tumor M2-like phenotype via a RAGE-STAT3 signaling axis, creating a resistant, tumor-promoting niche [178].