The immunogenic potential of this pathway is further highlighted by studies showing that environmental toxins like PCB29-pQ induce pyroptosis through HMGB1-TLR4-NLRP3-GSDMD signaling [190], while in leukemia, arsenic trioxide-induced pyroptosis promotes HMGB1 release that activates natural killer cell-mediated immunogenic cell death [191]. Here, HMGB1 is linked to leukemia.