PGP and cancer: MDR represents one of the most formidable obstacles in cancer therapy, largely due to the overexpression of multidrug resistance proteins (MRPs), such as ATP-binding cassette (ABC) transporters, particularly P-glycoprotein (P-gp/ABCB1), members of the MRPs family (MRPS1–9), and ABCG2, that actively efflux chemotherapeutic drugs [193].