The pro-tumorigenic potential of pyroptosis-derived HMGB1 extends to microenvironment remodeling, as evidenced in the recent study of Gao et al. in colorectal cancer, where Caspase-6/GSDMC-mediated tumor cell pyroptosis leads to HMGB1 release that enhances CXCL2 expression, subsequently recruiting MDSCs to create an immunosuppressive microenvironment conducive to tumor progression and immune evasion [188]. The gene discussed is HMGB1; the disease is neoplasm.