This was shown by Liu et al. in acute myeloid leukemia (AML), where etoposide-induced necroptosis promotes HMGB1 release, yet the extracellular HMGB1 itself activates NF-κB signaling that prevents necroptosis in surrounding AML cells, creating a self-limiting death process that may contribute to therapeutic resistance [155]. Here, NFKB1 is linked to acute myeloid leukemia.