Accordingly, newly emerging studies reinforce this immunostimulatory potential, such as in pancreatic ductal adenocarcinoma, where the inhibition of macrophage-capping protein (MCP) suppresses PIR, downregulates GPX4, and drives robust ferroptosis accompanied by accelerated HMGB1 cytosolic accumulation and release. This evidence concerns the gene CAPG and pancreatic ductal adenocarcinoma.