For example on HMGB1 roles in immunosuppression, studies delineating the temporal stages of ferroptosis reveal that HMGB1 release is a hallmark of the ‘terminal’ phase, and that cells undergoing ferroptosis can potently suppress dendritic cell (DC) maturation, antigen cross-presentation, and subsequent anti-tumor T-cell immunity, thereby actively impeding the adaptive immune response [175]. Here, HMGB1 is linked to neoplasm.