The therapeutic potential of blocking this specific pathway was demonstrated by the natural compound Lucidone, which was shown to inhibit the HMGB1/RAGE/PI3K/Akt axis, thereby suppressing both autophagic flux and MDR1 expression and consequently restoring chemosensitivity in gemcitabine-resistant pancreatic cancer cells [98]. The gene discussed is AKT1; the disease is pancreatic neoplasm.