A recent study by Zhao et al. demonstrated that HMGB1 function as a ferroptosis suppressor in hepatocellular carcinoma, while Astragaloside IV directly binds HMGB1, represses its expression, and thereby induces GPX4-dependent ferroptotic death in hepatocellular carcinoma, suggesting that HMGB1 can act as a protective brake against oxidative collapse [170]. This evidence concerns the gene GPX4 and hepatocellular carcinoma.