In a Chinese ccRCC cohort, the most common genomic alterations occur in the VHL, TP53, SETD2, BAP1, and PBRM1 genes with VHL and TP53 genes demonstrating a high mutation frequency and the PBRM1 gene demonstrating a low mutation frequency [19]. The gene discussed is SETD2; the disease is nonpapillary renal cell carcinoma.