In addition to the chromosome 3p loss, the most common mutated genes involved in ccRCC include: 1 von Hippel–Lindau Tumor Suppressor (VHL), 2 Polybromo 1 (PBRM1), 3 SET Domain Containing 2 (SETD2)-Histone Lysine Methyltransferase, 4 Lysine Demethylase 5C (KDM5C), 5 BRCA1 Associated Protein 1 (BAP1), 6 Phosphatase And Tensin Homolog (PTEN), 7 Mechanistic Target Of Rapamycin Kinase (mTOR), 8 Tumor Protein P53 (TP53), and 9 Phosphatidylinositol-4, 5-Bisphosphate 3-Kinase Catalytic Subunit Alpha (PIK3CA) [12,13,14]. The gene discussed is KDM5C; the disease is nonpapillary renal cell carcinoma.