Subsequently, through the PPI network, 12 core targets with the highest specificity for neurodegenerative diseases were identified: NFKB1, PPARG, SERPINE1, PPARA, NOS3, NFE2L2, SLC2A1, CSNK2A2, CSNK2A1, PLAU, PTGS1, TOP1, and CA9. The gene discussed is TOP1; the disease is neurodegenerative disease.