SP1 and osteogenesis imperfecta: In [25,26,27,28,29,30,31,32], it has been proven that TGF-β and its activator SP1 [26], the c-Met [27,28,29,30], sclerostin [31], Smad-3 [32], and MMP-13 [33] genes are involved in the genesis of osteogenesis imperfecta.