CD8A and neoplasm: Altogether, the immune microenvironment in the high-risk group shows indications of higher exhausted CD8+ T-cells, dendritic cells, and M1/2 macrophages, in addition to the higher infiltration of stromal contents such as fibroblasts and MSCs, suggesting an immunologically active but dysfunctional tumor microenvironment (inflamed but exhausted), which may explain the poor prognosis seen in this group.