Dysregulation of these receptors and their downstream signaling pathways, including PI3K/AKT/mTOR, Ras/Raf/MAPK, and phospholipase C (PLCγ), has been implicated in tumor progression and it is associated with poor prognosis, although the mechanism by which this happens is still unclear [14]. The gene discussed is AKT1; the disease is neoplasm.