Cytokines with anti-tumor properties including GM-CSF, IL-1α, IL-1β, IL-12, and IFN-γ were abundantly secreted in tumors without MTAP deletion, while anti-inflammatory cytokines such as RANTES, HGF, VEGF, IL-6, IL-8, and IL-9 were more represented in tissue with MTAP deletion. This evidence concerns the gene MTAP and neoplasm.