In samples derived from patients with L-SIL we observed the loss of the nuclear expression of REST in comparison to the samples without SIL, in this group around 84% of the cells show a mild to moderate expression in the nucleus, and found that around 16% of the samples were negative by using the 5G2 antibody, 4% with the scFv and the 8% with the F-3 antibody. This evidence concerns the gene REST and squamous cell intraepithelial neoplasia.