During the analysis of the samples derived from woman without SIL we observed that independently of the infection by the HR-HPV, 100% of the samples express REST in the 96% of the cells in the nucleus and cytoplasm with 5G2 antibody and the 100% shows expressing of REST in nucleus and cytoplasm with the scFv and F-3 antibody, mostly cells with moderate to intense staining independently of the antibody used. Here, REST is linked to squamous cell intraepithelial neoplasia.