SFRP5 and heart disorder: Wang et al. [37] reported a 2.3-fold rise in myocardial WNT5a in heart failure patients (p < 0.01), while Kelly et al. [38] found significantly lower plasma SFRP5 in heart disease (1.25 ± 0.35 ng/mL vs. 2.46 ± 0.96 ng/mL, p < 0.01).