Of note, tumor capacity to shape TME by producing a variety of cytokines, including TGF-8, IL-10, and VEGF, and attracting immunoregulatory cells, including regulatory T cells (Tregs), myeloid-derived suppressor cells (MDSCs), and tumor-associated macrophages (TAMs) is central to the regulation of TME [2]. This evidence concerns the gene VEGFA and neoplasm.