One of the recognized ways is that the evasion of immune response in cancer cells enhances the growth and development of cancerous cells through immune evasion via down-regulation of immune checkpoints (e.g., PD-L1), recruitment of immunosuppressive cells (e.g., Tregs, MDSCs), and release of inhibitory cytokines into the microenvironment of the tumor (TME). The gene discussed is CD274; the disease is neoplasm.