Tumor microenvironment (TME) is an active, immunosuppressive niche where both the expression pattern of anti-inflammatory cytokines (e.g., IL-10, TGF-beta) as well as the suppressor cell populations (In other words, the regulatory T cells [CD4+CD25+FOXP3+], myeloid derived suppressor cells [CD11b+Gr1+], and M2-polarized tumor associated macrophages [CD206+, IL10+]) is hyperactive. Here, CD4 is linked to neoplasm.