Furthermore, microRNA-208 is a cardiac-specific microRNA encoded within the Myh6 gene (Myosin Heavy Chain 6) (miR-208a) and Myh7 (Myosin Heavy Chain 7) gene (miR-208b), which plays a central role in the regulation of cellular pathways involved in hypertrophy in Heart Failure with Preserved Ejection Fraction (HFpEF). The gene discussed is MYH6; the disease is heart failure.