Taurine upregulated gene 1 (TUG-1) is a long noncoding RNA that, besides myocardial fibrosis, potentiates hypertrophy, apoptosis, autophagy, and inflammation with a confirmed role in the development of HFpEF through several studies [109,110,111,112]. The gene discussed is TUG1; the disease is Myocardial fibrosis.