Mouse models lacking laforin (Epm2a−/−) [30] or malin (Epm2b−/−) [31] expression exhibit neurological alterations that closely resemble those observed in patients with LD, including the presence of LBs, dyskinesia, impaired motor activity and coordination, deficits in episodic memory, and epileptic activity. This evidence concerns the gene EPM2A and Dyskinesia.