In HCC, both DNMT3A and GMPS’ effects on OS are associated with a broad depletion of lymphoid subsets (basophils, B cells, CD4+/CD8+ T cells, eosinophils, MSC), while enriching macrophages, NK T cells, Tregs, Th1/Th2 cells, and maintaining high mutation burden. The gene discussed is DNMT3A; the disease is hepatocellular carcinoma.