Moreover, the differential engagement of TLR pathways—TLR2-driven self-sensing signatures are prominent in PDAC and additional TLRs may contribute [44], self-sensing (TLR2/6) in PDAC versus viral-sensing (TLR3/4/7) in HCC—suggests that innate immune recognition mechanisms contribute to these distinct survival associations. The gene discussed is TLR3; the disease is hepatocellular carcinoma.