TGFB1 and neoplasm: In keeping with these dualistic roles, the TCGA analysis identified two immune subclasses inside the immune group: an adaptive T cell response subtype with the best outcome and an exhausted T cell/TGF-β-high subtype with significantly worse survival [41]; hence, vigorous, TLR-driven antiviral/Th1 immunity favors tumor control, whereas a TLR-TGF-β axis that subverts immunity heralds shorter OS.