When primary human tumor-associated stroma (TAS) was incubated with pancreatic-cancer-conditioned medium, robust secretion of IL-6 and IL-8 ensued; the phenomenon was MyD88-dependent and directly suppressed CD4+ and CD8+ T cell proliferation while skewing the balance towards Th17 and away from Th1 cells [37]. The gene discussed is CD4; the disease is familial pancreatic carcinoma.