CRP and periodontitis: Supporting this hypothesis, robust scientific evidence has demonstrated a positive correlation between periodontitis and elevated levels of inflammatory biomarkers, such as C-reactive protein (CRP) [29,30], tumor necrosis factor-alpha (TNF-α) [31,32], and interleukins 1β and 6 (IL-1β, IL-6) [33], which tend to decrease following periodontal treatment [34,35,36].