Our recent bioinformatics-led studies support the role of high levels of a specific TGF-β isoform, Transforming Growth Factor Beta 2 (TGFB2), and report that TGFB2 gene methylation serves as a significant prognostic marker in adult glioblastoma (GBM) [25] and pancreatic adenocarcinoma (PDAC) [26,27]. This evidence concerns the gene TGFB2 and glioblastoma.