Eleven genes exhibited greater than 4-fold increases in tumor tissues (RYR1, SPOCK2, ENTPD2, CITED4, MTHFD2, CDCA3, IDH2, SNTB1, PNP, PTPN6, MAP7; Median (Range) of fold increase = 6.1 (4.3–8)) (Figure 1; Table S1). The gene discussed is MTHFD2; the disease is neoplasm.