MYCN and neuroendocrine neoplasm: The MYCN gene consistently promotes the progression of MYCN-related neuroendocrine tumours by driving dynamic spatial and temporal interactions, including distinct transcriptional programmes, DNA damage repair, resolving torsional stress, regulating R-loops, metabolic networks, stress–response, and apoptosis-related signalling patterns, and contributing to the aggressive phenotype of MYCN-amplified diseases [38,39].