N-bisphosphonates interfere with farnesyl pyrophosphate synthase (FPPS) within the mevalonate pathway, blocking the prenylation of small GTPases (Ras/Rho/Rac) essential for cytoskeletal dynamics, invasion, and survival; this results in tumor-cell apoptosis and diminished adhesion/invasion in vitro [232,233]. Here, FDPS is linked to neoplasm.