In vivo inhibition of RANKL-mediated signaling (utilizing OPG Fc, a RANKL decoy) blocked the ovariectomy-induced transformation of dormant breast cancer disseminated tumor cells into growing bone lesions, demonstrating that RANKL-driven osteoclast activity is essential for resorption-mediated reactivation in mice. This evidence concerns the gene TNFSF11 and neoplasm.