By upregulating RANKL and pro-inflammatory/pro-angiogenic cytokines (e.g., VEGF, IL 6), NE/epinephrine acts at β2 AR on osteoblasts/osteocytes, boosting osteoclastogenesis and facilitating tumor cell adherence and vascularization in bone [144,148,149]. This evidence concerns the gene VEGFA and neoplasm.