The redirection of NK effector cells is an area of growing interest due to their ability to target multiple tumor antigens, to enhance in vivo proliferation and survival, and to increase infiltration of immune-deserted “cold tumors.” For example, IL-15 and IFN-α secretion may overcome resistance mechanisms in solid tumor microenvironments, as demonstrated by others [43,47]. The gene discussed is IL15; the disease is neoplasm.