GPC3 and hepatocellular carcinoma: We characterized both the expression and function of the two CAR constructs, namely CAR-GPC3-IL15 and CAR-GPC3-IL15-IFNα, and provided evidence that supports the potential use of soluble cytokine IFN-α to enhance anti-GPC3-specific primary CAR-NK cell function in hepatocellular carcinoma.