TRPV3 and Alzheimer disease: Preclinical investigations using cytokine-induced keratinocyte models of AD have shown that IDC and IDL exert synergistic effects that preserve epidermal barrier integrity, mitigate dysregulated keratinocyte differentiation, and suppress key inflammatory mediators, including IL1B, ITGA5, TSLP, TRPV3 and TRPA1.