The main metabolic pathways determined in T-2 intervention group and control groups at each of the time point, such as arachidonic acid metabolism, mitochondrial DNA depletion syndrome, adenine phosphoribosyltransferase deficiency (Supplementary Table S6) and mTOR signaling pathway, inflammatory mediator regulation of TRP channels and thyroid hormone synthesis (Figure 2D–G and Supplementary Table S7). This evidence concerns the gene APRT and mitochondrial DNA depletion syndrome.