Examining a biomarker panel (Aβ42/40, p-tau181, p-tau231, t-tau, NF-L, GFAP, UCHL-1, SNAP-25) in matched CSF and plasma samples across the AD continuum revealed strong correlations for Aβ42/40, p-tau181, p-tau231, NF-L, and GFAP between the two biofluids, whereas t-tau and UCHL-1 showed no correlation [202]. The gene discussed is SNAP25; the disease is Alzheimer disease.