Both ADAMTS1 and ADAMTS16, promote lung cancer metastasis in animal models: ADAMTS1 accelerates spontaneous pulmonary metastasis of Lewis lung carcinoma in C57BL/6 mice, while ADAMTS16 enhances pulmonary metastasis of A549 cells following tail vein injection in nude mice [16,48]. The gene discussed is ADAMTS1; the disease is lung cancer.