PLOD1 and Ehlers-Danlos syndrome: Our findings about decreased collagen fiber diameter in EDS patients with PLOD1 defects align with the mild fibril narrowing reported in aortic tissue in PLOD1-caused familial thoracic aortic aneurysms and dissections, a common feature with kyphoscoliotic EDS [20]; similarly to our results, collagen content was unaffected [21].