APOE and aortic atherosclerosis: BRL37344 (Table 1) in apolipoprotein E (ApoE)-deficient mice (animal model for hypercholesterolaemia and atherosclerosis) significantly reduces serum total cholesterol levels and deposition of free cholesterol, as well as cholesterol esters in the rat aorta (indicator of aortic atherosclerosis) [129], along with serum triglycerides, total cholesterol, and the VLDL/LDL ratio.