In ischemic stroke models, SPRC upregulated cluster of differentiation 24 (CD24) expression via the CBS/H2S signaling pathway, suppressing NF-κB and enhancing src/focal adhesion kinase/proline-rich tyrosine kinase 2 (Src/Fak/Pyk2)-dependent microglial migration [62]. This evidence concerns the gene SPRR3 and ischemic stroke.