AKR1B1 and diabetic neuropathy: Moreover, NaHS attenuated degeneration of dorsal root ganglion neurons and sciatic nerve axons in diabetic neuropathy by activating antioxidant enzymes such as superoxide dismutase (SOD) and superoxide dismutase 2 (SOD2) and downregulating aldose reductase expression (Figure 2a, Table 1) [31].