MAPT and early-onset autosomal dominant Alzheimer disease: Moreover, many molecular-cellular mechanisms in ischemia overlap with Alzheimer’s disease, including accumulation of misfolded proteins like Aβ and tau, activation of reactive astrocytes, impaired APP proteolysis, and BBB permeability [172], allowing for limited extrapolation of Aβ neurotoxicity model results to neurotrauma pathogenesis.