According to the study by Li et al. in a group of 115 SjD patients, a specific defect in the 2,5-oligoadenylate synthetase 1 (OAS1) led to resistance to IFN γ, hence leading to elevated concentrations of this cytokine and consequently increased risk of lymphoma, neuropathy and severe fatigue [38]. This evidence concerns the gene OAS1 and neuropathy.