INS and type 2 diabetes mellitus: A simplified model allowed independent variation in insulin peak amplitude, width, and overlap Results show that, relative to thrice-daily feeding (the reference regimen with stable triglyceride content over one month), infrequent meals (1–2/day) reduce, while frequent meals (5–8/day) increase triglyceride accumulation—most strongly in healthy individuals and attenuated in type 2 diabetes, as parameterized from the literature.