SORT1 and Familial prostate cancer: Specific epitopes on the biomarkers, Sortilin (transport, metabolic control, cell survival and signal transduction) and Syndecan-1 (integral membrane protein involved in endosomal uptake of lipids/cytokines/chemokines, and with functional roles in cell proliferation, invasion, angiogenesis, host defense and matrix modeling) enable visualization of the specific pathology in prostate cancer tissue that aligns with the different morphologies used in grading (Figure 1).