PFN-1 and ENO-1 were enriched in the PPI of subjects that have both DL and P. Furukawa et al. [38] also found that in the salivary proteome, PFN-1 in the T2DM+P group and ENO-1 in individuals with P were upregulated compared with the healthy group. This evidence concerns the gene PFN1 and type 2 diabetes mellitus.