The periodontitis-only group exhibited increased expression of proteins involved in cytoskeletal remodeling and cell junction regulation (with only one red MCODE cluster that physically connected the VIRMA (Vir-Like M6A Methyltransferase-Associated), AHNAK2, and KMT2A proteins), reflecting local inflammatory remodeling of periodontal tissues (Figure 5). This evidence concerns the gene AHNAK2 and periodontitis.