Additional immune-regulatory loci include MICA/MICB, CTLA4, PTPN22, CIITA, CLEC16A, CD274 (PD-L1), and NLRP1 (NALP1)—variants shared with other autoimmune diseases, underscoring common immune checkpoints rather than AAD-specific genes. Here, NLRP1 is linked to autoimmune disease.