In autoimmune Addison’s disease (AAD), candidate-gene and GWAS data converge on HLA-DR3/DR4 with replicated non-HLA signals (CTLA4, PTPN22, BACH2, SH2B3) and common AIRE effects, extending an “AIRE dosage” concept from rare monogenic APS-1 into common, complex autoimmunity. The gene discussed is PTPN22; the disease is chronic primary adrenal insufficiency.