Epigenetic profiling in CD4+ T-cells has reported global hypomethylation in AAD relative to controls, with a majority of differentially methylated regions (DMRs) in promoter elements and an overall skew toward hypomethylation; these patterns are comparable to those observed across other organ-specific autoimmune diseases and may reflect persistent activation states in disease-relevant pathways [8]. This evidence concerns the gene CD4 and autoimmune disease.