Clinically, PD patients with GBA1 mutations (GBA-PD) tend to have: earlier age at onset (typically 5–10 years earlier), more frequent cognitive impairment and dementia, more rapid progression of both motor and non-motor features, increased burden of Lewy pathology, and in some cases increased autonomic dysfunction [15,16]. The gene discussed is GBA1; the disease is Cognitive impairment.