APOE and coronary artery disorder: Among six common ApoE genotypes (three homozygous: ε2/ε2, ε3/ε3, ε4/ε4; three heterozygous: ε2/ε3, ε3/ε4, ε2/ε4), those carrying at least one ε4 allele (i.e., ε2/ε4, ε3/ε4, and especially ε4/ε4) exhibit a consistently higher risk of CAD due to the adverse effects of ε4 on lipid regulation.