Additionally, patients with tongue squamous cell carcinoma, the most common site for OSCC, demonstrated the greatest correlations with Cyclin D1 overexpression and parameters such as nodal status, histopathological grade, and TNM clinical staging, highlighting the utility of Cyclin D1 as a biomarker in this aggressive type of OSCC [51,52,53]. The gene discussed is CCND1; the disease is tongue squamous cell carcinoma.