CHCHD2 and Parkinson disease: In 2015, two missense CHCHD2 variants, p.(Thr61Ile) and p.(Arg145Gln), and the splice site CHCHD2 variant c.300 + 5G>A were identified in Japanese families with late-onset autosomal dominant PD [51] and later these variants were found in PD patients of Chinese origin [50].