To date, multiple genes have been linked to DCM, including ACTC1, BAG3, DES, DSG2, DSP, FLNC, LMNA, MYBPC, MYH6, MYH7, MYPN, PKP2, PLN, RBM20, SCN5A, TMPO, TNNT, TPM1, and TTN [2,34]. This evidence concerns the gene DES and familial dilated cardiomyopathy.