Due to ambiguous results from previous studies on the utility of BIN1 and TOMM40 genotyping, coupled with the increasing incorporation of molecular biology approaches in identifying biomarkers and therapeutic targets for neurodegenerative disorders, this study aimed to evaluate the potential of polymorphism genotyping in these genes as early markers of neurodegenerative disease onset. The gene discussed is TOMM40; the disease is neurodegenerative disease.