HSPA8 and rosacea: In rosacea, proteomic and transcriptomic investigations have revealed enrichment of neurodegeneration-related proteins such as SNCA, GSK3B, and HSPA8, as well as regulatory hubs including PPARG, STAT4, and RORA, which converge on NF-κB, IL-17, and TNF signaling pathways [62,64].