The core clinical features are Global Developmental Delay (GDD) and Intellectual Disability (ID) related with expressive language severely impaired, with many individuals remaining nonverbal1; hypotonia, present in a majority of individuals (79%) from infancy and contributing to significant motor delays3; epilepsy, that affect most individuals (64–100%) and are often medically refractor but in some reported cases, other therapeutic modalities such as the ketogenic diet and adrenocorticotropic hormone (ACTH) have also been ineffective in achieving seizure control. The gene discussed is POMC; the disease is Intellectual disability.