MED25 and Charcot-Marie-Tooth disease: Another study describes the discovery of the p.A335V mutation in the MED25 gene among a large family from Costa Rica, showing an inheritance pattern of Charcot-Marie-Tooth (CMT) (MIM #605589) [82] disease [83] that is autosomal recessive, specifically associated with the CMT2B2 region on chromosome 19q13.3.