POMC and Global developmental delay: The core clinical features are Global Developmental Delay (GDD) and Intellectual Disability (ID) related with expressive language severely impaired, with many individuals remaining nonverbal1; hypotonia, present in a majority of individuals (79%) from infancy and contributing to significant motor delays3; epilepsy, that affect most individuals (64–100%) and are often medically refractor but in some reported cases, other therapeutic modalities such as the ketogenic diet and adrenocorticotropic hormone (ACTH) have also been ineffective in achieving seizure control.