MED25 and COFS syndrome: Mutations in MED25 are linked to the pathogenesis of syndromes involving intellectual disability accompanied by eye and brain abnormalities, Warburg micro syndrome (MIM #600118) [76], Kaufman oculo-cerebro-facial syndrome (MIM #244450) [77], Cerebro-oculo-facio-skeletal syndrome (COFS) (MIM #214150) [78], Kahrizi syndrome (MIM #612713) [79], and other syndromes [80].