MED12 and FG syndrome: Hemizygous MED12 variations are linked to several X-linked developmental syndromes, including Opitz-Kaveggia syndrome (FG syndrome) (MIM #305450) [27], Lujan-Fryns syndrome (MIM #309520) [28], and X-linked Ohdo syndrome (MIM #300895) [29], alongside non-X-linked intellectual disability (ID) syndrome [30].