COL2A1 and Stickler syndrome: RRD is related to pathological mechanical changes in the vitreoretinal interface (e.g., posterior vitreous detachment, PVD; lattice degeneration, 30–46% of RRD); thus, genetic variants in collagen genes (e.g., COL2A1, COL11A1, COL18A1) are logically implicated in Stickler syndrome [76,79,83].