The enrichment of these categories reflects the dysregulation of transcriptional programs typical of keratinocytes (e.g., SPRR1/2/3, KRT10/KRT16, LOR, IVL, EVPL, SCEL, TGM1/TGM3, CERS3, ACER1, DSP) and, above all, the epithelial crosstalk that influences melanoma biology. This evidence concerns the gene SPRR1B and melanoma.