TP53 and neoplasm: A careful genomic characterization of six established invasive breast cancer CR cultures (number of passages between 5 and 10) in comparison to the original primary breast tumours by genome-wide array CGH, targeted next-generation sequencing, and global miRNA expression revealed a similar level of copy number alterations (>95% of overlap of cytobands), the retention of specific somatic variants (specifically for the TP53, FLT3, JAK3, KDR, PIK3CA, and CDKN2A genes), and global miRNA profiling clustering of CR and primary tumours [110].