Interestingly, the rearrangement includes at one extremity the lncRNA miR-17-92a-1 cluster host gene (MIR17HG) that exerts oncogenic effects in RB via the miR-155-5p/HIF-1α axis [26] and the hsa-mir-425-5p/MDM2 pathway [27]. Here, HIF1A is linked to retinoblastoma.