Some studies showed lower levels of serum inactive MGP as an important indicator of severe vascular calcification and poorer outcome in renal disease, while others demonstrated a progressive rise in plasma dephosphorylated–uncarboxylated MGP (dp-ucMGP) levels with CKD stages, aortic calcification scores [37], and aortic stenosis, as well as calcification status in type II diabetes and heart disease [38,39]. This evidence concerns the gene MGP and type 2 diabetes mellitus.