A study by Rodrigo Valenzuela et al. further demonstrated that unsaturated fatty acids promote fatty acid oxidation via PPAR-α activation and suppress lipogenesis through downregulation of SREBP-1c, while their oxidation products activate Nrf2, eliciting antioxidant and anti-fibrotic responses [36].The evolving landscape of NAFLD research, as revealed by our bibliometric analysis, demonstrates a clear paradigm shift from a focus on foundational pathological mechanisms to a concerted effort in developing nutritional interventions. The gene discussed is SREBF1; the disease is metabolic dysfunction-associated steatotic liver disease.