At the same time, that of PI3K and AKT1 decreased, and the dyslipidemia, aortic intima, and liver lesions improved to a certain extent, suggesting that CGE can regulate vascular wall cells by regulating the TGF-β/PI3K/AKT1 signaling pathways associated with tissue homeostasis. The gene discussed is TGFB1; the disease is metabolic syndrome.